<i>KCNJ5</i> Somatic Mutations in Aldosterone-Producing Adenoma Are Associated With a Worse Baseline Status and Better Recovery of Left Ventricular Remodeling and Diastolic Function

Primary aldosteronism is the most common secondary endocrine form of hypertension and causes many cardiovascular injuries. KCNJ5 somatic mutations have recently been identified in aldosterone-producing adenoma. However, their impacts on left ventricular remodeling precluding interference age, sex, blood pressure are still uncertain. We enrolled 184 adenoma patients who received adrenalectomy. Clinical, biochemical, echocardiographic data were analyzed preoperatively 1 year postoperatively. gene sequencing was performed. After propensity score matching for body mass index, pressure, duration, number hypertensive medications, there 60 each group with without mutations. The mutation carriers had higher index (LVMI) inappropriately excessive LVMI (ieLVMI) lower e′ than noncarriers. adrenalectomy, greater decreases ieLVMI In addition, only a significant decrease E/e′ after surgery. multivariate analysis, baseline correlated mutations, systolic pressure. Baseline medications. regression both surgery mainly changes Aldosterone-producing adrenalectomy those also benefited from regard to diastolic function, whereas noncarriers did not.